All Phenotypes Tg(HLA-B39/H2-D/B2m)2Dvs MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(HLA-B39/H2-D/B2m)2Dvs
transgene insertion 2, David V Serreze
MGI:6119476

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs Tg(HLA-B39/H2-D/B2m)2Dvs/?	NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-D1^b-em5Dvs Tg(HLA-B39/H2-D/B2M)2Dvs/Dvs	MGI:6119478

Allelic Composition	H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs Tg(HLA-B39/H2-D/B2m)2Dvs/?
Genetic Background	NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-D1^b-em5Dvs Tg(HLA-B39/H2-D/B2M)2Dvs/Dvs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1^b-em5Dvs mutation (4 available); any H2-D1 mutation (45 available)
H2-K1^d-em1Dvs mutation (4 available); any H2-K1 mutation (59 available)
Tg(HLA-B39/H2-D/B2m)2Dvs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

insulitis ( J:257229 )

immune system

insulitis ( J:257229 )

autoimmune response ( J:257229 )

increased susceptibility to autoimmune diabetes ( J:257229 )

• despite the absence of endognenous MHC class I, female carriers of this transgene have insulitis and development of autoimmune diabetes comparable to that of wild-type NOD

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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