All Phenotypes Tagln2<tm1Cdj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tagln2^tm1Cdj
targeted mutation 1, Chang-Duk Jun
MGI:6118987

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tagln2^tm1Cdj/Tagln2^tm1Cdj	involves: 129S4/SvJae * C57BL/6	MGI:6119491
cx2	Tagln2^tm1Cdj/Tagln2^tm1Cdj Tg(TcraTcrb)425Cbn/0	involves: 129S4/SvJae * C57BL/6	MGI:6119492
cx3	Tagln2^tm1Cdj/Tagln2^tm1Cdj Tg(TcraTcrb)1100Mjb/0	involves: 129S4/SvJae * C57BL/6	MGI:6119493

Allelic Composition	Tagln2^tm1Cdj/Tagln2^tm1Cdj
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln2^tm1Cdj mutation (0 available); any Tagln2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:256656 )

N	• no abnormalities in secondary lymphoid organ weight or size, T cell development, or B cell development are detected • B-cell and dendritic cell response to lipopolysaccharide is similar to controls

abnormal T cell physiology ( J:256656 )

• CD3+ T cells show impaired cell spreading and F-actin ring formation following stimulation on anti-CD3/28-coated coverslips

• CD3+ T cells show reduced conjugate formation with SEE-loaded CD19+ B cells from wild-type mice and impaired ability to adhere to ICAM-1

abnormal cytotoxic T cell physiology ( J:256656 )

• CD8+ T cells appear to have reduced cytotoxicity

hematopoietic system

abnormal T cell physiology ( J:256656 )

• CD3+ T cells show impaired cell spreading and F-actin ring formation following stimulation on anti-CD3/28-coated coverslips

• CD3+ T cells show reduced conjugate formation with SEE-loaded CD19+ B cells from wild-type mice and impaired ability to adhere to ICAM-1

abnormal cytotoxic T cell physiology ( J:256656 )

• CD8+ T cells appear to have reduced cytotoxicity

Allelic Composition	Tagln2^tm1Cdj/Tagln2^tm1Cdj Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln2^tm1Cdj mutation (0 available); any Tagln2 mutation (20 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell activation ( J:256656 )

• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

hematopoietic system

abnormal T cell activation ( J:256656 )

• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

Allelic Composition	Tagln2^tm1Cdj/Tagln2^tm1Cdj Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln2^tm1Cdj mutation (0 available); any Tagln2 mutation (20 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell activation ( J:256656 )

• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

hematopoietic system

abnormal T cell activation ( J:256656 )

• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

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