Phenotypes associated with this allele

• Allele Symbol: Hacd1^tm1Akih
• Allele Name: targeted mutation 1, Akio Kihara
• Allele ID: MGI:6118922
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hacd1^tm1Akih/Hacd1^tm1Akih	B6.129P2-Hacd1^tm1Akih/Akih	MGI:6118945
ht2	Hacd1^tm1Akih/Hacd1^+	B6.129P2-Hacd1^tm1Akih/Akih	MGI:6118951

Genotype
MGI:6118945

hm1

• Allelic Composition: Hacd1^tm1Akih/Hacd1^tm1Akih
• Genetic Background: B6.129P2-Hacd1^tm1Akih/Akih

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:247117 )

• at ages 1 month and 6 months

decreased body weight ( J:247117 )

• at ages 1 month and 6 months

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:247117 )

N • sphingomyelin, phosphatidylcholine and phosphatidylinositol levels in skeletal muscle

N • metabolism of exogenously supplied fatty acids in cultured myoblasts-derived myotube cells

abnormal enzyme/coenzyme activity ( J:247117 )

• 40% reduction in 3-hydroxyacyl-CoA dehydratase activity

muscle

decreased gastrocnemius weight ( J:247117 )

• at ages 1 month and 6 months

limbs/digits/tail

decreased gastrocnemius weight ( J:247117 )

• at ages 1 month and 6 months

Genotype
MGI:6118951

ht2

• Allelic Composition: Hacd1^tm1Akih/Hacd1⁺
• Genetic Background: B6.129P2-Hacd1^tm1Akih/Akih

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:247117 )

N • sphingomyelin, phosphatidylcholine and phosphatidylinositol levels in skeletal muscle

abnormal enzyme/coenzyme activity ( J:247117 )

• 20% reduction in 3-hydroxyacyl-CoA dehydratase activity