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Hacd1tm1Akih
Targeted Allele Detail
Summary
Symbol: Hacd1tm1Akih
Name: 3-hydroxyacyl-CoA dehydratase 1; targeted mutation 1, Akio Kihara
MGI ID: MGI:6118922
Gene: Hacd1  Location: Chr2:14031642-14060846 bp, - strand  Genetic Position: Chr2, 10.3 cM, cytoband A2
Alliance: Hacd1tm1Akih page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:247117
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsUsing recombineering techniques, exon 6, coding for an active site, was replaced with a loxP site flanked neomycin resistance gene cassette. (J:247117)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hacd1 Mutation:  16 strains or lines available
References
Original:  J:247117 Sawai M, et al., The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem. 2017 Sep 15;292(37):15538-15551
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory