About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pgrmc2tm1.1Jjp
targeted mutation 1.1, John J Peluso
MGI:6118911
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118932
cn2
 		Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118933
cn3
 		Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118934
cn4
 		Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118935


Genotype
MGI:6118932
cn1
Allelic
Composition		 Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (6 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
early reproductive senescence ( J:247103 )
• 50% of female mice become infertile after the third parity

reproductive system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
early reproductive senescence ( J:247103 )
• 50% of female mice become infertile after the third parity
abnormal endometrium morphology ( J:247103 )
• breakdown of basement membrane and disruption of epithelial-stromal interface
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium
reduced female fertility ( J:247103 )
• despite normal ovulation, female mice have fewer pups per litter and fewer litters per female compared with control mice
• however, weanling weights are normal
decreased litter size ( J:247103 )
• fewer pups per litter and fewer litters per female

homeostasis/metabolism
decreased circulating progesterone level ( J:247103 )
• marginally at 10.5 days of pregnancy

embryo
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

immune system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

endocrine/exocrine glands
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

hematopoietic system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

growth/size/body
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months




Genotype
MGI:6118933
cn2
Allelic
Composition		 Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (6 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

reproductive system
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium




Genotype
MGI:6118934
cn3
Allelic
Composition		 Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (10 available)
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (6 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
abnormal endometrium morphology ( J:247103 )
• breakdown of basement membrane and disruption of epithelial-stromal interface
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium
reduced female fertility ( J:247103 )
• female mice have fewer pups per litter and fewer litters per female compared with control mice
decreased litter size ( J:247103 )
• fewer pups per litter and fewer litters per female

endocrine/exocrine glands
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

growth/size/body
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months




Genotype
MGI:6118935
cn4
Allelic
Composition		 Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (10 available)
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (6 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

reproductive system
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory