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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cemiptm1.1Tac
targeted mutation 1.1, Taconic
MGI:6117713
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cemiptm1.1Tac/Cemiptm1.1Tac
Tg(Plp1-cre/ERT)3Pop/0 		involves: C57BL/6 * C57BL/6NTac * DBA/2 MGI:6117717
cn2
 		Cemiptm1.1Tac/Cemiptm1.1Tac
Tg(Dhh-cre)1Mejr/0 		involves: C57BL/6NTac * FVB/N MGI:6117715


Genotype
MGI:6117717
cn1
Allelic
Composition		 Cemiptm1.1Tac/Cemiptm1.1Tac
Tg(Plp1-cre/ERT)3Pop/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cemiptm1.1Tac mutation (0 available); any Cemip mutation (67 available)
Tg(Plp1-cre/ERT)3Pop mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Schwann cell physiology ( J:244311 )
• tamoxifen-treated myelinated Schwann cells in culture exhibit reduced dedifferentiation compared with wild-type cells




Genotype
MGI:6117715
cn2
Allelic
Composition		 Cemiptm1.1Tac/Cemiptm1.1Tac
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cemiptm1.1Tac mutation (0 available); any Cemip mutation (67 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:244311 )
• transient acceleration of postnatal myelination
• however, adult myelination is normal

homeostasis/metabolism
abnormal response to injury ( J:244311 )
• following nerve axotomy or sciatic nerve crush, mice exhibit reduced myelin degradation and increases remyelination compared with wild-type mice
• however, sciatic function index and Von Frey threshold are normal after nerve crush




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory