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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspb7tm1.1Chen
targeted mutation 1.1, Ju Chen
MGI:6116705
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hspb7tm1.1Chen/Hspb7tm1.1Chen
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:6159009
cn2
 		Hspb7tm1.1Chen/Hspb7tm1.1Chen
Tg(Tnnt2-cre)5Blh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:6159010


Genotype
MGI:6159009
cn1
Allelic
Composition		 Hspb7tm1.1Chen/Hspb7tm1.1Chen
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspb7tm1.1Chen mutation (0 available); any Hspb7 mutation (14 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

General and heart phenotype of Hspb7tm1.1Chen/Hspb7tm1.1Chen Nkx2-5tm1(cre)Rjs/Nkx2-5+ mice

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:256653 )
• most embryos died by E12.5, with no live embryos recovered at E13.5, similar to Hspb7tm1.2Chen homozygotes

cardiovascular system
abnormal heart morphology ( J:256653 )
• overall heart phenotype is stated to be similar to that observed in Hspb7tm1.2Chen homozygotes




Genotype
MGI:6159010
cn2
Allelic
Composition		 Hspb7tm1.1Chen/Hspb7tm1.1Chen
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspb7tm1.1Chen mutation (0 available); any Hspb7 mutation (14 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:256653 )
• all embryos died before E12.5 with an overall phenotype similar to that observed in Hspb7tm1.2Chen homozygotes; however no data are provided




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory