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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Frs3tm1Jheb
targeted mutation 1, Jean M Hebert
MGI:6116679
Summary 5 genotypes


Genotype
MGI:6116889
hm1
Allelic
Composition		 Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:242687 )
N
• adult mice show normal appearance

reproductive system




Genotype
MGI:6116891
cn2
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (87 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




Genotype
MGI:6116892
cn3
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (87 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:242687 )
N
• cell survival and cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity

nervous system
nervous system phenotype ( J:242687 )
N
• brain morphology at E12.5




Genotype
MGI:6116893
cn4
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (87 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:242687 )
N
• cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity
increased cell death ( J:242687 )
• according to TUNEL assay at E8.75

nervous system




Genotype
MGI:6116890
cn5
Allelic
Composition		 Foxg1tm1(cre)Skm/Foxg1+
Frs2tm1Fwan/Frs2tm1Fwan
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Frs2tm1Fwan mutation (0 available); any Frs2 mutation (64 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:242687 )
N
• differentiating field of cortical GABAergic interneurons at E13.5 according to Shh and Lhx6 labeling
abnormal cortical ventricular zone morphology ( J:242687 )
• reduced size of Dlx2-labeled region at E13.5
telencephalon hypoplasia ( J:242687 )
• reduction in size across A/P (-24%) and D/V (-16%) axes at E13.5
abnormal embryonic/fetal subventricular zone morphology ( J:242687 )
• reduced cell division at E13.5 according to mitotic marker p-HH3 immunoreactivity
abnormal lateral ganglionic eminence morphology ( J:242687 )
• reduction in subset of dopaminergic olfactory interneuron progenitors in dorsal LGE at E13.5 according to Pax6 labeling
abnormal medial ganglionic eminence morphology ( J:242687 )
• reduced size of Nkx2-1-labeled region in MGE and pre-optic area at E13.5
• size of Nkx2-1-labeled region in MGE and pre-optic area at E10.5
• reduced size of Lhx8-labeled differentiating domain at E13.5

craniofacial
frontonasal prominence hypoplasia ( J:242687 )
• at E10.5 and E13.5

vision/eye
microphthalmia ( J:242687 )
• at E13.5

cellular
cellular phenotype ( J:242687 )
N
• cell survival in telencephalon at E10.5 and E13.5




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory