Analysis Tools
mortality/aging
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• about a 50% reduction of homozygous embryos at E11.5 and E13.5
• however, the remainder of homozygous embryos are viable
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homeostasis/metabolism
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• decrease in liver total iron content
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hematopoietic system
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• decreased iron deposition in reticuloendothelial cells detected by histochemical analysis
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behavior/neurological
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• about 50% of survivors develop a head tilt at approximately 2 months of age
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• about 50% of survivors develop a circling behavior in the same direction as the head tilt at approximately 2 months of age
• this behavior becomes more prominent and increases in incidence with age
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nervous system
| N |
• total iron levels in the cerebral cortex and striatum are similar to wild-type controls
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liver/biliary system
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• decrease in liver total iron content
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immune system
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• decreased iron deposition in reticuloendothelial cells detected by histochemical analysis
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