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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem192tm2d(EUCOMM)Hmgu
targeted mutation 2d, Helmholtz Zentrum Muenchen GmbH
MGI:6115602
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem192tm2d(EUCOMM)Hmgu/Tmem192tm2d(EUCOMM)Hmgu involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL MGI:6117402


Genotype
MGI:6117402
hm1
Allelic
Composition		 Tmem192tm2d(EUCOMM)Hmgu/Tmem192tm2d(EUCOMM)Hmgu
Genetic
Background		 involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL
Cell Lines HEPD0785_6_G07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem192tm2d(EUCOMM)Hmgu mutation (0 available); any Tmem192 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:256294 )
• homozygotes are viable and overtly normal with no signs of pathology or lysosomal dysfunction in the brain, liver and spleen and no differences in major immune cell populations in the bone marrow, spleen, thymus or lymph nodes relative to wild-type controls
• MEFs show normal morphology of endo-/lysosomes with no alterations in autophagy or lysosomal exocytosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory