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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac2M4Btlr
mutation 4, Bruce Beutler
MGI:6114684
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rac2M4Btlr/Rac2M4Btlr C57BL/6J-Rac2M4Btlr MGI:6114688
ht2
 		Rac2M4Btlr/Rac2+ C57BL/6J-Rac2M4Btlr MGI:6114689


Genotype
MGI:6114688
hm1
Allelic
Composition		 Rac2M4Btlr/Rac2M4Btlr
Genetic
Background		 C57BL/6J-Rac2M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2M4Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
increased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
decreased IgE level ( J:255273 )
• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge
decreased IgG level ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:255273 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired natural killer cell mediated cytotoxicity ( J:255273 )
• educed natural killer cell-mediated target cell killing
abnormal cytotoxic T cell physiology ( J:255273 )
• reduced natural killer cell-mediated target cell killing
impaired humoral immune response ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

hematopoietic system
decreased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
increased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
decreased IgE level ( J:255273 )
• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge
decreased IgG level ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide
decreased IgM level ( J:255273 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired natural killer cell mediated cytotoxicity ( J:255273 )
• educed natural killer cell-mediated target cell killing
abnormal cytotoxic T cell physiology ( J:255273 )
• reduced natural killer cell-mediated target cell killing




Genotype
MGI:6114689
ht2
Allelic
Composition		 Rac2M4Btlr/Rac2+
Genetic
Background		 C57BL/6J-Rac2M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2M4Btlr mutation (0 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
decreased IgG level ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:255273 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
increased IgM level ( J:255273 )
• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge
abnormal cytotoxic T cell physiology ( J:255273 )
• reduced natural killer cell-mediated target cell killing
impaired humoral immune response ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased alpha-beta T cell number ( J:255273 )
• in the peripheral blood
decreased IgG level ( J:255273 )
• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:255273 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
increased IgM level ( J:255273 )
• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge
abnormal cytotoxic T cell physiology ( J:255273 )
• reduced natural killer cell-mediated target cell killing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory