About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl3m1Btlr
mutation 1, Bruce Beutler
MGI:6114031
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl3m1Btlr/Bcl3m1Btlr C57BL/6J-Bcl3m1Btlr MGI:6114033
ht2
 		Bcl3m1Btlr/Bcl3+ C57BL/6J-Bcl3m1Btlr MGI:6114034


Genotype
MGI:6114033
hm1
Allelic
Composition		 Bcl3m1Btlr/Bcl3m1Btlr
Genetic
Background		 C57BL/6J-Bcl3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl3m1Btlr mutation (0 available); any Bcl3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B-1 B cell number ( J:255184 )
• in the peripheral blood
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood
abnormal humoral immune response ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgG level ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
increased B-1 B cell number ( J:255184 )
• in the peripheral blood
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood
decreased IgG level ( J:255184 )
• reduced T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




Genotype
MGI:6114034
ht2
Allelic
Composition		 Bcl3m1Btlr/Bcl3+
Genetic
Background		 C57BL/6J-Bcl3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl3m1Btlr mutation (0 available); any Bcl3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood

hematopoietic system
decreased B cell number ( J:255184 )
• in the peripheral blood
decreased B-1b cell number ( J:255184 )
• in the peripheral blood
increased macrophage cell number ( J:255184 )
• in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory