Phenotypes associated with this allele

• Allele Symbol: Tnik^tm1Teya
• Allele Name: targeted mutation 1, Tesshi Yamada
• Allele ID: MGI:6113591
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnik^tm1Teya/Tnik^tm1Teya	involves: C57BL/6J	MGI:6113598
cx2	Apc^Min/Apc^+ Tnik^tm1Teya/Tnik^tm1Teya	involves: C57BL/6J	MGI:6113599

Genotype
MGI:6113598

hm1

• Allelic Composition: Tnik^tm1Teya/Tnik^tm1Teya
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:241611 )

homeostasis/metabolism

decreased circulating glucose level ( J:241611 )

decreased circulating cholesterol level ( J:241611 )

• total serum cholesterol levels are decreased

decreased circulating HDL cholesterol level ( J:241611 )

decreased incidence of tumors by chemical induction ( J:241611 )

• mice develop fewer colon tumors after administration of the carcinogen azoxymethane (AOM)

neoplasm

decreased incidence of tumors by chemical induction ( J:241611 )

• mice develop fewer colon tumors after administration of the carcinogen azoxymethane (AOM)

Genotype
MGI:6113599

cx2

• Allelic Composition: Apc^Min/Apc⁺; Tnik^tm1Teya/Tnik^tm1Teya
• Genetic Background: involves: C57BL/6J

digestive/alimentary system

decreased alimentary system tumor incidence ( J:241611 )

• mice develop significantly lower number of tumors in the small intestine and colon than single Apc^Min heterozygous mice

neoplasm

decreased alimentary system tumor incidence ( J:241611 )

• mice develop significantly lower number of tumors in the small intestine and colon than single Apc^Min heterozygous mice