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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Diaph1M1Btlr
mutation 1, Bruce Beutler
MGI:6113373
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Diaph1M1Btlr/Diaph1M1Btlr C57BL/6J-Diaph1M1Btlr MGI:6113375
ht2
 		Diaph1M1Btlr/Diaph1+ C57BL/6J-Diaph1M1Btlr MGI:6113376


Genotype
MGI:6113375
hm1
Allelic
Composition		 Diaph1M1Btlr/Diaph1M1Btlr
Genetic
Background		 C57BL/6J-Diaph1M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1M1Btlr mutation (0 available); any Diaph1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal CD8-positive, alpha-beta T cell number ( J:254820 )
• before and after MCMV infection
decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )
• after mouse cytomegalovirus (MCMV) infection
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration

hematopoietic system
abnormal CD8-positive, alpha-beta T cell number ( J:254820 )
• before and after MCMV infection
decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )
• after mouse cytomegalovirus (MCMV) infection
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration




Genotype
MGI:6113376
ht2
Allelic
Composition		 Diaph1M1Btlr/Diaph1+
Genetic
Background		 C57BL/6J-Diaph1M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1M1Btlr mutation (0 available); any Diaph1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration

immune system
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory