About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Diaph1M1Btlr
mutation 1, Bruce Beutler
MGI:6113373
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Diaph1M1Btlr/Diaph1M1Btlr C57BL/6J-Diaph1M1Btlr MGI:6113375
ht2
 		Diaph1M1Btlr/Diaph1+ C57BL/6J-Diaph1M1Btlr MGI:6113376


Genotype
MGI:6113375
hm1
Allelic
Composition		 Diaph1M1Btlr/Diaph1M1Btlr
Genetic
Background		 C57BL/6J-Diaph1M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1M1Btlr mutation (0 available); any Diaph1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal CD8-positive, alpha-beta T cell number ( J:254820 )
• before and after MCMV infection
decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )
• after mouse cytomegalovirus (MCMV) infection
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration

hematopoietic system
abnormal CD8-positive, alpha-beta T cell number ( J:254820 )
• before and after MCMV infection
decreased effector memory CD8-positive, alpha-beta T cell number ( J:254820 )
• after mouse cytomegalovirus (MCMV) infection
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration




Genotype
MGI:6113376
ht2
Allelic
Composition		 Diaph1M1Btlr/Diaph1+
Genetic
Background		 C57BL/6J-Diaph1M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1M1Btlr mutation (0 available); any Diaph1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration

immune system
decreased IgE level ( J:254820 )
• after ovalbumin-alum administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory