Analysis Tools
digestive/alimentary system
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• at 10-11 weeks of age, mice show a significantly increased level of apoptosis of colonic epithelial cells in the proximal colon relative to wild-type controls
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• at 10-11 weeks of age, mice exhibit altered cell lineage differentiation of the colonic epithelium
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• at 10-11 weeks of age, colonocyte number is significantly decreased in the proximal colon relative to that in wild-type controls
• however, colonic crypt length and colonic epithelium proliferation are normal
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• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls
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cellular
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• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls
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• at 10-11 weeks of age, mice show a significantly increased level of apoptosis of colonic epithelial cells in the proximal colon relative to wild-type controls
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endocrine/exocrine glands
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• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls
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