Phenotypes associated with this allele

• Allele Symbol: Rufy3^tm1.1Migar
• Allele Name: targeted mutation 1.1, Michihirio Igarashi
• Allele ID: MGI:6111136
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rufy3^tm1.1Migar/Rufy3^tm1.1Migar	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:6120571

Genotype
MGI:6120571

hm1

• Allelic Composition: Rufy3^tm1.1Migar/Rufy3^tm1.1Migar
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

cyanosis ( J:253649 )

• resulting in neonatal lethality

mortality/aging

neonatal lethality, complete penetrance ( J:253649 )

nervous system

abnormal neuron morphology ( J:253649 )

• multiple-axon formation in embryonic cortical neurons after two days in vitro

• multiple neurites formed 30 min. after plating of neurons on laminin

• neurites formed independent from glycoprotein m6a (Gpm6a) clusters in membrane

• reduced number of unipolar neurons, increased number of multi-polar/apolar neurons

abnormal neurite morphology ( J:253649 )

• multiple neurites formed 30 min. after plating of neurons on laminin

• neurites formed independent from glycoprotein m6a (Gpm6a) clusters in membrane

abnormal axon morphology ( J:253649 )

• multiple-axon formation in embryonic cortical neurons after two days in vitro

abnormal neuron polarity ( J:253649 )

• multiple-axon formation in embryonic cortical neurons after two days in vitro

• reduced number of unipolar neurons, increased number of multi-polar/apolar neurons