All Phenotypes Hltf<tm1.1Hdin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hltf^tm1.1Hdin
targeted mutation 1.1, Hao Ding
MGI:6108112

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apc^Min/Apc⁺ Hltf^tm1.1Hdin/Hltf^tm1.1Hdin	involves: 129 * C57BL/6 * FVB/N	MGI:6108175
cx2	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^{Gt(RRJ453)Byg}/Shprh^{Gt(RRJ453)Byg}	involves: 129 * C57BL/6 * SJL	MGI:6108258
cx3	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^tm1Jhjh/Shprh^tm1Jhjh	involves: 129 * C57BL/6 * SJL	MGI:6108259

Allelic Composition	Apc^Min/Apc⁺ Hltf^tm1.1Hdin/Hltf^tm1.1Hdin
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:252991 )

• aneuploidy owing to nonreciprocal translocations, chromosomal fusions (dicentric chromosomes, centromeric fusions, missing telomeres) and chromosomal fragments and breaks in cultured colon tumor cells

neoplasm

neoplasm ( J:252991 )

N	• average 65 macroscopic intestine adenocarcinoma tumors per mouse, similar to wild-type • average 1.5 macroscopic colon adenocarcinoma tumors per mouse, similar to wild-type

increased metastatic potential ( J:252991 )

• invasive intestinal adenocarcinomas (deeper invasion of tumor cells into muscularis propria of small intestine)

• high beta-catenin activity in invaded neoplastic glandular cells in small intestine

• most colon tumors displayed a more severe glandular atypia resulting in formation of many mucin-filled cysts

• most colon tumors displayed strong desmoplastic stromal reaction

• higher beta-catenin activity in colon tumor cells

• transplanted colon tumor cells are malignant

Allelic Composition	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^{Gt(RRJ453)Byg}/Shprh^{Gt(RRJ453)Byg}
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)
Shprh^{Gt(RRJ453)Byg} mutation (0 available); any Shprh mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177630 )

N	• normal somatic hypermutation frequency and spectrum in JH4 intronic region in germinal center B cells

Allelic Composition	Hltf^tm1.1Hdin/Hltf^tm1.1Hdin Shprh^tm1Jhjh/Shprh^tm1Jhjh
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hltf^tm1.1Hdin mutation (0 available); any Hltf mutation (47 available)
Shprh^tm1Jhjh mutation (0 available); any Shprh mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177630 )

N	• class switch recombination in primary-activated B cells • normal somatic hypermutation frequency and spectrum in JH4 intronic region in germinal center B cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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