About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thap1tm1.2Meeh
targeted mutation 1.2, Michelle E Ehrlich
MGI:6107688
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thap1tm1.2Meeh/Thap1tm1.2Meeh involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6 MGI:6107697
ht2
 		Thap1tm1.2Meeh/Thap1+ involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6 MGI:6107698
ht3
 		Thap1tm1.1Meeh/Thap1tm1.2Meeh involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6 MGI:6107699


Genotype
MGI:6107697
hm1
Allelic
Composition		 Thap1tm1.2Meeh/Thap1tm1.2Meeh
Genetic
Background		 involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1tm1.2Meeh mutation (0 available); any Thap1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal axon extension ( J:226849 )
• few Tuj1-immunopositive neurons
• no obvious processes on Tuj1-immunopositive neurons

liver/biliary system

mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:226849 )
• most embryos died by E10, but rare survivors up to E14

nervous system
abnormal axon extension ( J:226849 )
• few Tuj1-immunopositive neurons
• no obvious processes on Tuj1-immunopositive neurons

vision/eye




Genotype
MGI:6107698
ht2
Allelic
Composition		 Thap1tm1.2Meeh/Thap1+
Genetic
Background		 involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1tm1.2Meeh mutation (0 available); any Thap1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:226849 , J:226849 )
• increase in foot-slips on narrow beam in beam walking challenge (J:226849)
• 10% decrease in forepaw base width and 20% increase in front and hind paw overlap (J:226849)
• slower in both orienting downwards and descending in pole test (J:226849)
• 5% increase in forepaw stride length and 17% increase in forepaw base width (J:226849)
• faster orienting downwards in pole test (J:226849)

nervous system
abnormal cerebellum dentate nucleus morphology ( J:226849 )
• hypocellularity: 40% decrease in cell number

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
torsion dystonia 6 DOID:0090039 OMIM:602629
 J:226849




Genotype
MGI:6107699
ht3
Allelic
Composition		 Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic
Background		 involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1tm1.1Meeh mutation (0 available); any Thap1 mutation (33 available)
Thap1tm1.2Meeh mutation (0 available); any Thap1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal axon extension ( J:226849 )
• few Tuj1-immunopositive neurons
• no obvious processes on Tuj1-immunopositive neurons

liver/biliary system

mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:226849 )
• most embryos died by E10, but rare survivors up to E14

nervous system
abnormal axon extension ( J:226849 )
• few Tuj1-immunopositive neurons
• no obvious processes on Tuj1-immunopositive neurons

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory