All Phenotypes Cdr1os<em1Nikr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdr1os^em1Nikr
endonuclease-mediated mutation 1, Nikolaus Rajewsky
MGI:6107169

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Cdr1os^em1Nikr/Y	C57BL/6N-Cdr1os^em1Nikr	MGI:6107177

Allelic Composition	Cdr1os^em1Nikr/Y
Genetic Background	C57BL/6N-Cdr1os^em1Nikr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdr1os^em1Nikr mutation (0 available); any Cdr1os mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal action potential ( J:249957 )

• altered responses to two consecutive stimuli and to a train of action potentials at 10 Hz

• stronger depression in synaptic response

• more than double frequency of spontaneous vesicle release in hippocampal neurons

• amplitude unchanged

decreased prepulse inhibition ( J:249957 )

• 30-50% reduction using 120 dB acoustic pre-pulse

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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