Phenotypes associated with this allele

• Allele Symbol: Creld1^tm1.1Chlm
• Allele Name: targeted mutation 1.1, Cheryl L Maslen
• Allele ID: MGI:5912278
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Creld1^tm1.1Chlm/Creld1^tm1.1Chlm	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:5912293

Genotype
MGI:5912293

hm1

• Allelic Composition: Creld1^tm1.1Chlm/Creld1^tm1.1Chlm
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal forebrain development ( J:243757 )

• at E10.5

abnormal hindbrain development ( J:243757 )

• at E10.5

abnormal midbrain development ( J:243757 )

• at E10.5

cardiovascular system

absent organized vascular network ( J:243757 )

• in yolk sac at E10.5

• cephalic vascular trees failed to fully arborize and appeared more primitive at E10.5

atrioventricular cushion hypoplasia ( J:243757 )

• fewer cells and less extracellular matrix at E10.5

craniofacial

abnormal craniofacial morphology ( J:243757 )

• at E10.5

embryo

increased embryonic tissue cell apoptosis ( J:243757 )

• in the endocardial cushions and pharyngeal arches at E10.5 according to TUNEL assays

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:243757 )

• between E10.5 and E11.5

cellular

increased embryonic tissue cell apoptosis ( J:243757 )

• in the endocardial cushions and pharyngeal arches at E10.5 according to TUNEL assays