Creld1^tm1.1Chlm
Targeted Allele Detail

Summary

• Symbol: Creld1^tm1.1Chlm
• Name: cysteine-rich with EGF-like domains 1; targeted mutation 1.1, Cheryl L Maslen
• MGI ID: MGI:5912278
• Gene: Creld1 Location: Chr6:113460317-113470304 bp, + strand Genetic Position: Chr6, 52.77 cM
• Alliance: Creld1^tm1.1Chlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243757
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of intron 1 (1.9 kb total) were deleted by replacement with a self-excising cassette comprising the following elements: a loxP site, the testis-specific angiotensin I converting enzyme (Ace) promoter, the cre recombinase gene, RNA polymerase II, a neomycin resistance gene, and a second loxP site. (J:243757)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creld1 Mutation: 30 strains or lines available

Notes

ES cell line = D15T44

References

• Original: J:243757 Redig JK, et al., Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genet. 2014;1(1):1-19
• All: 2 reference(s)