About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpainem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5911998
Summary 3 genotypes


Genotype
MGI:6377560
hm1
Allelic
Composition		 Rpainem1(IMPC)J/Rpainem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Rpainem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpainem1(IMPC)J mutation (2 available); any Rpain mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• normal looking blastocysts are present at lower than expected Mendelian ratios at E3.5 (7% versus 25%); no homozygous embryos are recovered at E7.5

embryo
decreased trophectoderm cell proliferation ( J:279207 )
• blastocysts hatch from the zona pellucida but form outgrowth colonies with few trophectoderm cells after 3 days in culture

cellular
decreased trophectoderm cell proliferation ( J:279207 )
• blastocysts hatch from the zona pellucida but form outgrowth colonies with few trophectoderm cells after 3 days in culture




Genotype
MGI:6394373
hm2
Allelic
Composition		 Rpainem1(IMPC)J/Rpainem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Rpainem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpainem1(IMPC)J mutation (2 available); any Rpain mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6370429
ht3
Allelic
Composition		 Rpainem1(IMPC)J/Rpain+
Genetic
Background		 C57BL/6NJ-Rpainem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpainem1(IMPC)J mutation (2 available); any Rpain mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

hearing/vestibular/ear

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory