Phenotypes associated with this allele

• Allele Symbol: Rpain^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5911998
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpain^em1(IMPC)J/Rpain^em1(IMPC)J	C57BL/6NJ-Rpain^em1(IMPC)J/Mmjax	MGI:6394373
ht2	Rpain^em1(IMPC)J/Rpain^+	C57BL/6NJ-Rpain^em1(IMPC)J/Mmjax	MGI:6370429

Genotype
MGI:6394373

hm1

• Allelic Composition: Rpain^em1(IMPC)J/Rpain^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Rpain^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Rpain

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rpain^em1(IMPC)J/Rpain^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocyts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths with few trophectoderm cells.

embryo

abnormal trophectoderm morphology ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form outgrowths with few trophectoderm cells after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• normal looking blastocysts are present at E3.5 (7% versus expected 25%, n=14); no homozygous embryos are recovered at E7.5

Genotype
MGI:6370429

ht2

• Allelic Composition: Rpain^em1(IMPC)J/Rpain⁺
• Genetic Background: C57BL/6NJ-Rpain^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Rpain

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - JAX

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

IMPC - JAX

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

IMPC - JAX