All Phenotypes Meis2<tm1.1Zkoz> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz Tfap2a^tm1(cre)Moon/Tfap2a⁺	involves: 129 * C57BL/6J	MGI:5911951
cn2	H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:7335064
cn3	Gt(ROSA)26Sor^{tm3(CAG-Shox2)Fawa}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:7335081

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz Tfap2a^tm1(cre)Moon/Tfap2a⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Meis2^tm1.1Zkoz mutation (0 available); any Meis2 mutation (29 available)
Tfap2a^tm1(cre)Moon mutation (1 available); any Tfap2a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal tongue muscle morphology ( J:229604 )

• disorganized tongue muscle fibers at E14

mortality/aging

neonatal lethality, complete penetrance ( J:229604 )

• die around the time of birth

cardiovascular system

abnormal cardiac neural crest cell morphology ( J:229604 )

• poor colonization of the outflow tract by cardiac neural crest cells at E10.5

abnormal cardiac outflow tract development ( J:229604 )

• poor colonization of the outflow tract by cardiac neural crest cells at E10.5

• at E11 the outflow tract has a lower density of cardiac neural crest cells and these cells are disorganized

• however, septation occurs normally

double outlet right ventricle ( J:229604 )

• in some embryos

abnormal heart valve morphology ( J:229604 )

• malformed outflow tract valves in 90% of mice at E12

nervous system

abnormal cardiac neural crest cell morphology ( J:229604 )

• poor colonization of the outflow tract by cardiac neural crest cells at E10.5

small trigeminal ganglion ( J:229604 )

• smaller and misshapen

abnormal facial nerve morphology ( J:229604 )

abnormal trigeminal nerve morphology ( J:229604 )

• less affected compared to germline null mice

abnormal vestibulocochlear nerve morphology ( J:229604 )

vision/eye

decreased cornea thickness ( J:229604 )

• at E17

failure of eyelid fusion ( J:229604 )

• fail to grow and close over the eye bulb at E17

skeleton

absent interparietal bone ( J:229604 )

abnormal parietal bone morphology ( J:229604 )

• boundary of ossification is abnormal

abnormal hyoid bone morphology ( J:229604 )

• severely malformed

abnormal mandible morphology ( J:229604 )

• poorly developed

short mandible ( J:229604 )

abnormal cartilage morphology ( J:229604 )

• severely malformed palatal cartilage in 33% of mice with less severe malformations in the remaining 67% of mice

• otic capsule cartilage is absent at E16 in 33% of mice and reduced in 66% of mice

hearing/vestibular/ear

abnormal otic capsule morphology ( J:229604 )

• cartilage is absent at E16 in 33% of mice and reduced in 66% of mice

craniofacial

absent interparietal bone ( J:229604 )

abnormal parietal bone morphology ( J:229604 )

• boundary of ossification is abnormal

abnormal hyoid bone morphology ( J:229604 )

• severely malformed

abnormal mandible morphology ( J:229604 )

• poorly developed

short mandible ( J:229604 )

abnormal palate morphology ( J:229604 )

• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice

abnormal tongue muscle morphology ( J:229604 )

• disorganized tongue muscle fibers at E14

decreased tongue size ( J:229604 )

• small tongue at E14

digestive/alimentary system

abnormal palate morphology ( J:229604 )

• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice

abnormal tongue muscle morphology ( J:229604 )

• disorganized tongue muscle fibers at E14

decreased tongue size ( J:229604 )

• small tongue at E14

growth/size/body

abnormal palate morphology ( J:229604 )

• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice

abnormal tongue muscle morphology ( J:229604 )

• disorganized tongue muscle fibers at E14

decreased tongue size ( J:229604 )

• small tongue at E14

embryo

abnormal cardiac neural crest cell morphology ( J:229604 )

• poor colonization of the outflow tract by cardiac neural crest cells at E10.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers

muscle

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

skeleton

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal intramembranous bone ossification ( J:286823 )

• in mice with submucous cleft palate, anterior shelves elevate and fuse but expression analysis indicates that osteogenesis fails to initiate

• however, osteogenesis does occur in the parts of the maxillary bone at either end of the nasal passage

digestive/alimentary system

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers

growth/size/body

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers

Allelic Composition	Gt(ROSA)26Sor^{tm3(CAG-Shox2)Fawa}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(CAG-Shox2)Fawa} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Meis2^tm1.1Zkoz mutation (0 available); any Meis2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:286823 )

craniofacial

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

cleft secondary palate ( J:286823 )

• complete cleft is seen in 9 of 14

submucous cleft palate ( J:286823 )

• in 5 of 14

• manifests as fused anterior palate and cleft soft palate

skeleton

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

digestive/alimentary system

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

cleft secondary palate ( J:286823 )

• complete cleft is seen in 9 of 14

submucous cleft palate ( J:286823 )

• in 5 of 14

• manifests as fused anterior palate and cleft soft palate

growth/size/body

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

cleft secondary palate ( J:286823 )

• complete cleft is seen in 9 of 14

submucous cleft palate ( J:286823 )

• in 5 of 14

• manifests as fused anterior palate and cleft soft palate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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