Phenotypes associated with this allele

• Allele Symbol: Runx3^{tm6(EGFP/cre)Yg}
• Allele Name: targeted mutation 6, Yoram Groner
• Allele ID: MGI:5911702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dynlrb1^tm1c(EUCOMM)Wtsi/Dynlrb1^tm1c(EUCOMM)Wtsi Runx3^tm6(EGFP/cre)Yg/Runx3^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N	MGI:6466702

Genotype
MGI:6466702

cn1

• Allelic Composition: Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi}; Runx3^{tm6(EGFP/cre)Yg}/Runx3⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
• Cell Lines: EPD0373_7_C01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:292124 )

• adult mice show an abnormal clenched hind-limb phenotype when suspended by the tail

abnormal motor coordination/balance ( J:292124 )

• adult mice exhibit impaired proprioception

impaired balance ( J:292124 )

• adult mice are unable to balance themselves on an accelerating rotarod

abnormal gait ( J:292124 )

• adult mice show an uncoordinated walking pattern with abdomen posture close to the ground and display an abnormal walking pattern in the catwalk

decreased locomotor activity ( J:292124 )

• adult mice exhibit reduced speed and less distance traveled than wild type controls in the open field

• however, basal motor activity is normal

nervous system

nervous system phenotype ( J:292124 )

N • mice show no significant alterations in neuromuscular junction size or numbers and in total (Tuj1 positive) or nociceptive (CGRP positive) skin innervation

abnormal proprioceptive neuron morphology ( J:292124 )

• the number of proprioceptive NFH-positive neurons in DRG ganglia is significantly decreased

• however, the number of CGRP-positive nociceptive neurons is normal