Phenotypes associated with this allele

• Allele Symbol: Rnaseh2b^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5911393
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnaseh2b^tm1c(EUCOMM)Wtsi/Rnaseh2b^tm1c(EUCOMM)Wtsi Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	MGI:5911410
cn2	Rnaseh2b^tm1c(EUCOMM)Wtsi/Rnaseh2b^tm1c(EUCOMM)Wtsi Tg(Pgk1-cre)1Lni/0	involves: BALB/c * C57BL/6 * C57BL/6N * SJL	MGI:5911413

Genotype
MGI:5911410

cn1

• Allelic Composition: Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi}; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL
• Cell Lines: EPD0087_4_A02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:186986 )

N • mice exhibit normal numbers of B cells in the spleen

decreased B cell proliferation ( J:186986 )

• LPS-induced

hematopoietic system

decreased B cell proliferation ( J:186986 )

• LPS-induced

cellular

decreased B cell proliferation ( J:186986 )

• LPS-induced

Genotype
MGI:5911413

cn2

• Allelic Composition: Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi}; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6N * SJL
• Cell Lines: EPD0087_4_A02

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:186986 )

• mice exhibit embryonic lethality similar to Rnaseh2c^tm1Roer homozygotes