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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Exoc2em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5909206
Summary 2 genotypes


Genotype
MGI:6377660
hm1
Allelic
Composition		 Exoc2em1(IMPC)J/Exoc2em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Exoc2em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exoc2em1(IMPC)J mutation (2 available); any Exoc2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• normal blastocysts are recovered at higher than expected Mendelian ratios at E3.5 (33% versus 25%); no homozygous embryos are recovered at E7.5

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

cellular
increased cell death ( J:279207 )
• blastocysts show apparent cell death after 3 days in culture




Genotype
MGI:6394289
hm2
Allelic
Composition		 Exoc2em1(IMPC)J/Exoc2em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Exoc2em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exoc2em1(IMPC)J mutation (2 available); any Exoc2 mutation (61 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory