Exoc2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Exoc2^em1(IMPC)J
• Name: exocyst complex component 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5909206
• Synonyms: Exoc2^-
• Gene: Exoc2 Location: Chr13:30968416-31158076 bp, - strand Genetic Position: Chr13, Syntenic
• Alliance: Exoc2^em1(IMPC)J page
• IMPC: Exoc2 gene page

Exoc2^em1(IMPC)J/Exoc2^em1(IMPC)J mice exhibit embryonic lethality after E3.5 but before E7.5. Blastocysts grown in vitro fail to hatch from the zona pellucida.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences ATATTTAGGGATATCCCACA, GGTAAAATTAAAGAACCAAA, and GTATTTGTTATAAGGCCAGC that targeted exon(s) ENSMUSE00000117295.2. This resulted in deletion(s) of 346 bp (location: Chr13:31119393-31119738; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Exoc2 Mutation: 64 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)