Phenotypes associated with this allele

• Allele Symbol: Gja10^{tm1.1(icre)Aah}
• Allele Name: targeted mutation 1.1, Arlene Hirano
• Allele ID: MGI:5908159
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gja10^tm1.1(icre)Aah/Gja10^+ Gt(ROSA)26Sor^tm1(CAG-cas9*,-EGFP)Fezh/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:7449212

Genotype
MGI:7449212

cn1

• Allelic Composition: Gja10^{tm1.1(icre)Aah}/Gja10⁺; Gt(ROSA)26Sor^{tm1(CAG-cas9*,-EGFP)Fezh}/?
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina horizontal cell morphology ( J:333740 )

• following infection with adeno-associated viruses that express a single-guide RNA targeting Amigo1 and a fluorescent reporter (AAV2/1-U6-sgAmigo1-CAG-tdTomato), the size of axons of infected horizontal cells is reduced and some branches stray into the outer nuclear layers

• however, the number of dendritic and axonal synapses and the size of horizontal cell dendrites is normal

nervous system

abnormal retina horizontal cell morphology ( J:333740 )

• following infection with adeno-associated viruses that express a single-guide RNA targeting Amigo1 and a fluorescent reporter (AAV2/1-U6-sgAmigo1-CAG-tdTomato), the size of axons of infected horizontal cells is reduced and some branches stray into the outer nuclear layers

• however, the number of dendritic and axonal synapses and the size of horizontal cell dendrites is normal