Phenotypes associated with this allele

• Allele Symbol: Kcnt2^tm1.2Clin
• Allele Name: targeted mutation 1.2, Christopher J Lingle
• Allele ID: MGI:5908119
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin	B6(Cg)-Kcnt2^tm1.2Clin	MGI:5908184
cx2	Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin	B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin	MGI:5908190

Genotype
MGI:5908184

hm1

• Allelic Composition: Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin
• Genetic Background: B6(Cg)-Kcnt2^tm1.2Clin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:228059 )

N • itch and pain responses are similar to wild type controls

Genotype
MGI:5908190

cx2

• Allelic Composition: Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin; Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin
• Genetic Background: B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin

behavior/neurological

decreased chemical nociceptive threshold ( J:228059 )

• enhanced aversion to moderate doses of capsaicin

decreased thermal nociceptive threshold ( J:228059 )

• briefer latency in a hot plate test

integument

increased pruritus ( J:228059 )

• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection

nervous system

abnormal action potential ( J:228059 )

• in isolectin B4+ neurons increase in action potential firing and a decrease in threshold is seen

decreased channel response intensity ( J:228059 )

• absence of Na+-dependent leak current in dissociated small diameter dorsal root ganglions neurons