All Phenotypes Kcnt2<tm1.2Clin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnt2^tm1.2Clin
targeted mutation 1.2, Christopher J Lingle
MGI:5908119

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin	B6(Cg)-Kcnt2^tm1.2Clin	MGI:5908184
cx2	Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin	B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin	MGI:5908190

Allelic Composition	Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin
Genetic Background	B6(Cg)-Kcnt2^tm1.2Clin

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt2^tm1.2Clin mutation (0 available); any Kcnt2 mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:228059 )

N	• itch and pain responses are similar to wild type controls

Allelic Composition	Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin
Genetic Background	B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1^tm1.2Clin mutation (0 available); any Kcnt1 mutation (66 available)
Kcnt2^tm1.2Clin mutation (0 available); any Kcnt2 mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased chemical nociceptive threshold ( J:228059 )

• enhanced aversion to moderate doses of capsaicin

decreased thermal nociceptive threshold ( J:228059 )

• briefer latency in a hot plate test

integument

increased pruritus ( J:228059 )

• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection

nervous system

abnormal action potential ( J:228059 )

• in isolectin B4+ neurons increase in action potential firing and a decrease in threshold is seen

decreased channel response intensity ( J:228059 )

• absence of Na+-dependent leak current in dissociated small diameter dorsal root ganglions neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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