All Phenotypes Cfap157<tm1d(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cfap157^{tm1d(EUCOMM)Hmgu}
targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI:5907283

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfap157^{tm1d(EUCOMM)Hmgu}/Cfap157^{tm1d(EUCOMM)Hmgu}	involves: C57BL/6 * SJL	MGI:6104239

Allelic Composition	Cfap157^{tm1d(EUCOMM)Hmgu}/Cfap157^{tm1d(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfap157^{tm1d(EUCOMM)Hmgu} mutation (1 available); any Cfap157 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:237484 )

• bulge in proximal flagellum

abnormal sperm midpiece morphology ( J:237484 )

• axonemal loop in 93% of sperm

• surplus cytoplasm in axonemal loop

• bulge in 6% of sperm

• ectopic fibrous sheath close to sperm head and reduced sheath in principal piece in 80% of sperm

• accumulation of mitochondria near axonemal link

abnormal sperm head morphology ( J:237484 )

• dislocated in 75% of sperm

absent sperm head ( J:237484 )

• in 12% of sperm

decreased male germ cell number ( J:237484 )

abnormal sperm motility ( J:237484 )

• reduced

• abnormal (twitching or local circular movement)

decreased hyperactivated sperm motility ( J:237484 )

• inefficient binding to eggs and barely moving eggs in vitro

abnormal cauda epididymis morphology ( J:237484 )

• fewer sperm

male infertility ( J:237484 )

• left vaginal plugs in timed matings but produced no offspring

• continuous matings (3-5 months) yielded no offspring

cellular

abnormal cell morphology ( J:237484 )

• sperm isolated from cauda epididymis

abnormal sperm flagellum morphology ( J:237484 )

• bulge in proximal flagellum

abnormal sperm midpiece morphology ( J:237484 )

• axonemal loop in 93% of sperm

• surplus cytoplasm in axonemal loop

• bulge in 6% of sperm

• ectopic fibrous sheath close to sperm head and reduced sheath in principal piece in 80% of sperm

• accumulation of mitochondria near axonemal link

abnormal sperm head morphology ( J:237484 )

• dislocated in 75% of sperm

absent sperm head ( J:237484 )

• in 12% of sperm

decreased male germ cell number ( J:237484 )

abnormal sperm motility ( J:237484 )

• reduced

• abnormal (twitching or local circular movement)

decreased hyperactivated sperm motility ( J:237484 )

• inefficient binding to eggs and barely moving eggs in vitro

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