Phenotypes associated with this allele

• Allele Symbol: Pnpla1^tm1.1Murm
• Allele Name: targeted mutation 1.1, Makoto Murakami
• Allele ID: MGI:5906480
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnpla1^tm1.1Murm/Pnpla1^tm1.1Murm Tg(KRT14-cre/ERT2)1Ipc/0	involves: C57BL/6N	MGI:5906503

Genotype
MGI:5906503

cn1

• Allelic Composition: Pnpla1^tm1.1Murm/Pnpla1^tm1.1Murm; Tg(KRT14-cre/ERT2)1Ipc/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:240682 )

• mice die within 6 days of birth

integument

impaired skin barrier function ( J:240682 )

• severe defect

abnormal epidermis stratum corneum morphology ( J:240682 )

• lower zone of the layers are densely packed with lipid-poor interspaces

epidermal desquamation ( J:240682 )

• focal

homeostasis/metabolism

impaired skin barrier function ( J:240682 )

• severe defect

abnormal ceramide level ( J:240682 )

• reduced esterified omega-hydroxyacyl-sphingosine and acylglucosylceramide but increased ceramide levels in the epidermis