All Phenotypes Pnpla1<tm1.1Murm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pnpla1^tm1.1Murm
targeted mutation 1.1, Makoto Murakami
MGI:5906480

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnpla1^tm1.1Murm/Pnpla1^tm1.1Murm Tg(KRT14-cre/ERT2)1Ipc/0	involves: C57BL/6N	MGI:5906503

Allelic Composition	Pnpla1^tm1.1Murm/Pnpla1^tm1.1Murm Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpla1^tm1.1Murm mutation (0 available); any Pnpla1 mutation (28 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:240682 )

• mice die within 6 days of birth

integument

impaired skin barrier function ( J:240682 )

• severe defect

abnormal epidermis stratum corneum morphology ( J:240682 )

• lower zone of the layers are densely packed with lipid-poor interspaces

epidermal desquamation ( J:240682 )

• focal

homeostasis/metabolism

impaired skin barrier function ( J:240682 )

• severe defect

abnormal ceramide level ( J:240682 )

• reduced esterified omega-hydroxyacyl-sphingosine and acylglucosylceramide but increased ceramide levels in the epidermis

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