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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nop53tm2.1Asuz
targeted mutation 2.1, Akira Suzuki
MGI:5906164
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nop53tm2.1Asuz/Nop53tm2.1Asuz
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)#Jxm/0 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:5906184
cn2
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:5906183
cn3
 		Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5906173


Genotype
MGI:5906184
cn1
Allelic
Composition		 Nop53tm2.1Asuz/Nop53tm2.1Asuz
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)#Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased thymocyte number ( J:241062 )
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO

hematopoietic system
decreased thymocyte number ( J:241062 )
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO

immune system
decreased thymocyte number ( J:241062 )
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO




Genotype
MGI:5906183
cn2
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control

hematopoietic system
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control

immune system
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control




Genotype
MGI:5906173
cn3
Allelic
Composition		 Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control

hematopoietic system
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control

immune system
decreased thymocyte number ( J:241062 )
• thymocyte level was 5% of control




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory