Phenotypes associated with this allele

• Allele Symbol: P3h4^tm1.2Rmr
• Allele Name: targeted mutation 1.2, Roy Morello
• Allele ID: MGI:5905852
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P3h4^tm1.2Rmr/P3h4^tm1.2Rmr	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:5905897

Genotype
MGI:5905897

hm1

• Allelic Composition: P3h4^tm1.2Rmr/P3h4^tm1.2Rmr
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal cutaneous collagen fibril morphology ( J:232567 )

• decreased density of collagen fibers

decreased skin tensile strength ( J:232567 )

• skin fragility with thinning of the muscle layer below the hypodermis

muscle

abnormal muscle morphology ( J:232567 )

• thinning of the muscle layer below the hypodermis

skeleton

abnormal bone collagen fibril morphology ( J:232567 )

• mice exhibit impaired collagen triple-helical lysine hydroxylation compared with wild-type mice

decreased trabecular bone volume ( J:232567 )

• in femur and tibia

decreased compact bone thickness ( J:232567 )

• in tibia, but not femur

decreased trabecular bone connectivity density ( J:232567 )

• in tibia, but not femur