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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zscan21tm1.1Jiwa
targeted mutation 1.1, Jiaxiang Wang
MGI:5904160
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Stra8-icre)1Reb/0
Zscan21tm1.1Jiwa/Zscan21tm1.1Jiwa 		involves: FVB/NJ MGI:5904161


Genotype
MGI:5904161
cn1
Allelic
Composition		 Tg(Stra8-icre)1Reb/0
Zscan21tm1.1Jiwa/Zscan21tm1.1Jiwa
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Stra8-icre)1Reb mutation (2 available)
Zscan21tm1.1Jiwa mutation (0 available); any Zscan21 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:237046 )
• testes show no round spermatids
abnormal spermatocyte morphology ( J:237046 )
• testes show few spermatocytes, without round spermatids
abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )
• unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis
arrest of male meiosis ( J:237046 )
• spermatocytes do not progress to meiotic prophase I
decreased testis weight ( J:237046 )
• testis weight of adult males is less than 40% of heterozygotes
male infertility ( J:237046 )
• males are infertile, with 6-8 week old males failing to produce offspring after natural mating with wild-type females for more than 4 months

cellular
abnormal spermatid morphology ( J:237046 )
• testes show no round spermatids
abnormal spermatocyte morphology ( J:237046 )
• testes show few spermatocytes, without round spermatids
abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )
• unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis
arrest of male meiosis ( J:237046 )
• spermatocytes do not progress to meiotic prophase I
abnormal double-strand DNA break repair ( J:237046 )
• failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci

endocrine/exocrine glands
decreased testis weight ( J:237046 )
• testis weight of adult males is less than 40% of heterozygotes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:237046 )
• failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory