Phenotypes associated with this allele

• Allele Symbol: Map3k20^em2Smun
• Allele Name: endonuclease-mediated mutation 2, Stefan Mundlos
• Allele ID: MGI:5903729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k20^em2Smun/Map3k20^em2Smun	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:5903753

Genotype
MGI:5903753

hm1

• Allelic Composition: Map3k20^em2Smun/Map3k20^em2Smun
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

polydactyly ( J:231477 )

• in two mice

abnormal hindlimb morphology ( J:231477 )

• 4 of 64 mice exhibit unilateral complex hindlimb duplication phenotype

• supernumerary hindlimb, with shortened femur, fibula and tibia but normal-sized foot, in 1 mouse at E18.5 connected to an imperfectly duplicated pelvic girdle

• one mouse exhibited a partial duplication of the right hindlimb and pelvic structure

skeleton

skeleton phenotype ( J:231477 )

N • mice exhibit normal forelimbs

abnormal pelvic girdle bone morphology ( J:231477 )

• imperfect duplicated pelvic girdle in two mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:231477 )

N • mice exhibit normal ears and Preyers reflex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
split hand-foot malformation		DOID:0090020	OMIM:PS183600	J:231477