Phenotypes associated with this allele

• Allele Symbol: Map3k14^tm1.2Gne
• Allele Name: targeted mutation 1.2, Genentech
• Allele ID: MGI:5903085
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k14^tm1.2Gne/Map3k14^tm1.2Gne	B6(Cg)-Map3k14^tm1.2Gne	MGI:5903232

Genotype
MGI:5903232

hm1

• Allelic Composition: Map3k14^tm1.2Gne/Map3k14^tm1.2Gne
• Genetic Background: B6(Cg)-Map3k14^tm1.2Gne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:240453 )

• increased numbers of medullary thymocytes

decreased B cell number ( J:240453 )

• in spleen, lymph nodes and bone marrow

decreased transitional stage T1 B cell number ( J:240453 )

• immature Cd23- and Cd23+ cells in the spleen were unaffected

decreased transitional stage T2 B cell number ( J:240453 )

• in the spleen

decreased germinal center B cell number ( J:240453 )

• significantly reduced in lymph nodes

decreased B-2 B cell number ( J:240453 )

• in the spleen

decreased follicular B cell number ( J:240453 )

• in the spleen

abnormal spleen marginal zone morphology ( J:240453 )

• incompletely developed

decreased marginal zone B cell number ( J:240453 )

• in the spleen

abnormal B cell physiology ( J:240453 )

• noncanonical Nfkb pathway signaling was absent after in vitro stimulation with anti-Cd40 antibody

• induction of the canonical pathway (as assessed by Nfkbib degradation) was unaffected after in vitro stimulation with anti-Cd40 antibody

decreased IgA level ( J:240453 )

absent Peyer's patches ( J:240453 )

small axillary lymph nodes ( J:240453 )

small brachial lymph nodes ( J:240453 )

absent inguinal lymph nodes ( J:240453 )

absent popliteal lymph nodes ( J:240453 )

hematopoietic system

abnormal thymus cell ratio ( J:240453 )

• increased numbers of medullary thymocytes

decreased B cell number ( J:240453 )

• in spleen, lymph nodes and bone marrow

decreased transitional stage T1 B cell number ( J:240453 )

• immature Cd23- and Cd23+ cells in the spleen were unaffected

decreased transitional stage T2 B cell number ( J:240453 )

• in the spleen

decreased germinal center B cell number ( J:240453 )

• significantly reduced in lymph nodes

decreased B-2 B cell number ( J:240453 )

• in the spleen

decreased follicular B cell number ( J:240453 )

• in the spleen

abnormal spleen marginal zone morphology ( J:240453 )

• incompletely developed

decreased marginal zone B cell number ( J:240453 )

• in the spleen

abnormal B cell physiology ( J:240453 )

• noncanonical Nfkb pathway signaling was absent after in vitro stimulation with anti-Cd40 antibody

• induction of the canonical pathway (as assessed by Nfkbib degradation) was unaffected after in vitro stimulation with anti-Cd40 antibody

decreased IgA level ( J:240453 )

endocrine/exocrine glands

abnormal thymus cell ratio ( J:240453 )

• increased numbers of medullary thymocytes