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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k14tm1.1Gne
targeted mutation 1.1, Genentech
MGI:5903065
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Map3k14tm1.1Gne/Map3k14tm1.1Gne 		B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte MGI:5903230
cn2
 		Map3k14tm1.1Gne/Map3k14tm1.1Gne
Otub1tm1c(EUCOMM)Hmgu/Otub1tm1c(EUCOMM)Hmgu
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * C57BL/6NTac MGI:6387022
cn3
 		Map3k14tm1.1Gne/Map3k14tm1.1Gne
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac MGI:6387020


Genotype
MGI:5903230
cn1
Allelic
Composition		 Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic
Background		 B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Map3k14tm1.1Gne mutation (0 available); any Map3k14 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:240453 )
N
• after tamoxifen treatment of adult mice
decreased B cell proliferation ( J:240453 )
• reduced response to Tnfsf13b in vitro 2 days, and in vivo 3 and 5 days after tamoxifen treatment
• lack of BrdU incorporation after Tnfsf13b induction in vivo 3 and 5 days after tamoxifen treatment
• proliferation in response to anti-Cd40 or anti-Ighm antibody induction
decreased B cell number ( J:240453 )
• in mesenteric lymph nodes and Peyers patches reductions in total B cells occurred as early as days 512 post-tamoxifen treatment, with further reductions occurring through the last time point examined at day 30 post-tamoxifen
decreased germinal center B cell number ( J:240453 )
• in mesenteric lymph nodes and Peyers patches
decreased IgA level ( J:240453 )
• severe reduction
decreased IgG1 level ( J:240453 )
• modest reduction
decreased IgM level ( J:240453 )
• modest reduction

hematopoietic system
decreased B cell proliferation ( J:240453 )
• reduced response to Tnfsf13b in vitro 2 days, and in vivo 3 and 5 days after tamoxifen treatment
• lack of BrdU incorporation after Tnfsf13b induction in vivo 3 and 5 days after tamoxifen treatment
• proliferation in response to anti-Cd40 or anti-Ighm antibody induction
decreased B cell number ( J:240453 )
• in mesenteric lymph nodes and Peyers patches reductions in total B cells occurred as early as days 512 post-tamoxifen treatment, with further reductions occurring through the last time point examined at day 30 post-tamoxifen
decreased germinal center B cell number ( J:240453 )
• in mesenteric lymph nodes and Peyers patches
decreased IgA level ( J:240453 )
• severe reduction
decreased IgG1 level ( J:240453 )
• modest reduction
decreased IgM level ( J:240453 )
• modest reduction

cellular
decreased B cell proliferation ( J:240453 )
• reduced response to Tnfsf13b in vitro 2 days, and in vivo 3 and 5 days after tamoxifen treatment
• lack of BrdU incorporation after Tnfsf13b induction in vivo 3 and 5 days after tamoxifen treatment
• proliferation in response to anti-Cd40 or anti-Ighm antibody induction




Genotype
MGI:6387022
cn2
Allelic
Composition		 Map3k14tm1.1Gne/Map3k14tm1.1Gne
Otub1tm1c(EUCOMM)Hmgu/Otub1tm1c(EUCOMM)Hmgu
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * C57BL/6NTac
Cell Lines HEPD0539_8_A05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Map3k14tm1.1Gne mutation (0 available); any Map3k14 mutation (41 available)
Otub1tm1c(EUCOMM)Hmgu mutation (0 available); any Otub1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:280549 )
N
• mice show a rescue of the B-cell defect seen in Otub1 conditional mice, with mice showing enhanced frequency and absolute number of peritoneal B2 cells
• mice show a rescue of the defect in B-cell maturation, with increased splenic mature B cells, particularly the MZ B cells




Genotype
MGI:6387020
cn3
Allelic
Composition		 Map3k14tm1.1Gne/Map3k14tm1.1Gne
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Map3k14tm1.1Gne mutation (0 available); any Map3k14 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:280549 )
• reduction in peripheral B cell numbers

immune system
decreased B cell number ( J:280549 )
• reduction in peripheral B cell numbers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory