Phenotypes associated with this allele

• Allele Symbol: Babam2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5898381
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Babam2^tm1b(EUCOMM)Wtsi/Babam2^tm1b(EUCOMM)Wtsi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5898383

Genotype
MGI:5898383

hm1

• Allelic Composition: Babam2^{tm1b(EUCOMM)Wtsi}/Babam2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:235690 )

N • male and female mice have normal appearance and fertility

cellular

increased fibroblast apoptosis ( J:235690 )

• after 7 passages and increasing at 11 passages

decreased fibroblast proliferation ( J:235690 )

• of fibroblasts after 3 days in culture

early cellular replicative senescence ( J:235690 )

• in fibroblasts after 11 passages, following gamma irradiation or after treatment with hydrogen peroxide

abnormal DNA repair ( J:235690 )

• impaired in irradiated fibroblasts

homeostasis/metabolism

abnormal DNA repair ( J:235690 )

• impaired in irradiated fibroblasts