All Phenotypes Del(XMagea1-Magea6)1Nju MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Del(XMagea1-Magea6)1Nju
deletion, Chr X, Model Animal Research Center for Nanjing University
MGI:5898330

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Del(XMagea1-Magea6)1Nju/Y Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:5902066

Allelic Composition	Del(XMagea1-Magea6)1Nju/Y Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(XMagea1-Magea6)1Nju mutation (0 available); any Del(XMagea1-Magea6)1Nju mutation (0 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oligozoospermia ( J:240206 )

• overall sperm count normal at P30 and 5 months

• decrease in the testicular sperm reserve at 2 months

increased cellular sensitivity to DNA damaging agents ( J:240206 )

• increased proportions of apoptotic and dead spermatocytes in the seminiferous tubules 24h after injection with DNA-damaging agent N-ethyl-N-nitrosourea (ENU) at 3 months

• higher levels of Trp53 protein in the testes 3 hours after ENU administration

• higher level of Ser15-phosphorylation of Trp53 in the testes 6 hours after ENU treatment

• increased level of apoptosis marker Bax in testes 6 hours after ENU treatment

increased male germ cell apoptosis ( J:240206 )

• increased apoptosis in spermatocytes at P12

endocrine/exocrine glands

small seminiferous tubules ( J:240206 )

• reduction in the area, diameter and perimeter of the seminiferous tubules at 3 months

decreased testis weight ( J:240206 )

• P30 and earlier

• average testicular mass to body mass ratio was 16.6% lower from 2 months

reproductive system

oligozoospermia ( J:240206 )

• overall sperm count normal at P30 and 5 months

• decrease in the testicular sperm reserve at 2 months

increased male germ cell apoptosis ( J:240206 )

• increased apoptosis in spermatocytes at P12

small seminiferous tubules ( J:240206 )

• reduction in the area, diameter and perimeter of the seminiferous tubules at 3 months

decreased testis weight ( J:240206 )

• P30 and earlier

• average testicular mass to body mass ratio was 16.6% lower from 2 months

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