All Phenotypes Smarca4<mos6> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smarca4^mos6
modifier of Sox10 6
MGI:5898019

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smarca4^mos6/Smarca4^mos6	involves: BALB/cJ * C57BL/6J	MGI:6241341
cx2	Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:6241342

Allelic Composition	Smarca4^mos6/Smarca4^mos6
Genetic Background	involves: BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4^mos6 mutation (0 available); any Smarca4 mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:241206 )

• no homozygous embryos are recovered at E9.5 or later time points

Allelic Composition	Smarca4^mos6/Smarca4⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4^mos6 mutation (0 available); any Smarca4 mutation (109 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

integument

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

embryo

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes

nervous system

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes

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