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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
transgene insertion 1, Jeffery Molkentin
MGI:5897311
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Plntm1Egk/Plntm1Egk
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: 129S2/SvPas * FVB MGI:5897396
cx2
 		Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: 129S6/SvEvTac * FVB MGI:5897404
cx3
 		Myh6tm1Jse/Myh6+
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: 129X1/SvJ * FVB MGI:5897392
cx4
 		Atp2a2tm1Ges/Atp2a2+
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: 129X1/SvJ * FVB MGI:5897399
cx5
 		Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: FVB MGI:5897383
cx6
 		Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: FVB MGI:5897405


Genotype
MGI:5897396
cx1
Allelic
Composition		 Plntm1Egk/Plntm1Egk
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation (7 available); any Pln mutation (16 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal interventricular septum morphology ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart weight ( J:234490 )
• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart left ventricle size ( J:234490 )
• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
abnormal myocardial fiber physiology ( J:234490 )
• faster mechanical relaxation of myocyte contraction compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
abnormal myocardial fiber calcium currents ( J:234490 )
• faster Ca2+ transient decay time compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol

growth/size/body
increased heart weight ( J:234490 )
• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice




Genotype
MGI:5897404
cx2
Allelic
Composition		 Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation (1 available); any Ppp3cb mutation (66 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
thin interventricular septum ( J:234490 )
• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart weight ( J:234490 )
• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart left ventricle size ( J:234490 )
• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
decreased cardiac muscle contractility ( J:234490 )
• more so than in Ppp3cbtm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle
decreased cardiac muscle contractility ( J:234490 )
• more so than in Ppp3cbtm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body
increased heart weight ( J:234490 )
• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice




Genotype
MGI:5897392
cx3
Allelic
Composition		 Myh6tm1Jse/Myh6+
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6tm1Jse mutation (2 available); any Myh6 mutation (206 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

cardiovascular system
abnormal interventricular septum morphology ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart weight ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart left ventricle size ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
abnormal cardiac muscle contractility ( J:234490 )
• mice exhibit improved fractional shortening compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle
abnormal cardiac muscle contractility ( J:234490 )
• mice exhibit improved fractional shortening compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body
increased heart weight ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice




Genotype
MGI:5897399
cx4
Allelic
Composition		 Atp2a2tm1Ges/Atp2a2+
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2a2tm1Ges mutation (1 available); any Atp2a2 mutation (76 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:234490 )
• more so than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart left ventricle size ( J:234490 )
• improved compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
abnormal myocardial fiber physiology ( J:234490 )
• increased unloaded twitch force

growth/size/body
increased heart weight ( J:234490 )
• more so than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice




Genotype
MGI:5897383
cx5
Allelic
Composition		 Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234490 )
• some mice die by 4 months of age with no mice surviving beyond 8 months

cardiovascular system
increased heart weight ( J:234490 )
• at baseline
abnormal myocardial fiber physiology ( J:234490 )
• reduced time at elevated tension with a set amount of Ca+2
• increased diastolic Ca2+ concentration

muscle
abnormal sarcomere morphology ( J:234490 )
• elongated and increased length-to-width ratios at baseline

growth/size/body
increased heart weight ( J:234490 )
• at baseline




Genotype
MGI:5897405
cx6
Allelic
Composition		 Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
thick interventricular septum ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol and wild-type mice
increased heart weight ( J:234490 )
• compared with wild-type mice
abnormal heart left ventricle morphology ( J:234490 )
• left ventricular wall thickness is increased compared with wild-type and Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
• however, left ventricle size is rescued compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased cardiac muscle contractility ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle
increased cardiac muscle contractility ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body
increased heart weight ( J:234490 )
• compared with wild-type mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory