All Phenotypes Opn3<tm2b(EUCOMM)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Opn3^{tm2b(EUCOMM)Wtsi}
targeted mutation 2b, Wellcome Trust Sanger Institute
MGI:5897190

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi}	involves: C57BL/6N * FVB/N	MGI:6457281
cx2	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA	MGI:5897203

Allelic Composition	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2b(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal beige fat cell morphology ( J:287419 )

• low beige content in inguinal white adipose tissue

abnormal white fat cell size ( J:287419 )

• larger size distribution

abnormal adipose tissue physiology ( J:287419 )

• reduced fat mobilization indicated by increased postmortem fat deposits

homeostasis/metabolism

abnormal homeostasis ( J:287419 )

• mice exhibit normal circadian phasing and respiratory exchange ratio

impaired adaptive thermogenesis ( J:287419 )

• following cold exposure, mice exhibit reduced core body temperature compared with control mice

decreased core body temperature ( J:287419 )

• following cold exposure

decreased energy expenditure ( J:287419 )

• in male mice housed at 10 Celcius

increased carbon dioxide production ( J:287419 )

decreased oxygen consumption ( J:287419 )

• in male mice housed at 10 Celcius

behavior/neurological

decreased fluid intake ( J:287419 )

decreased food intake ( J:287419 )

Allelic Composition	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA
Cell Lines	EPD0197_3_E01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2b(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (23 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:227078 )

N	• retinas exhibit normal circadian photoentrainment and corneal photoentrainment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23