Analysis Tools
mortality/aging
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• mice are born at a lower than the expected 25% Mendelian frequency
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growth/size/body
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• mice are smaller than control mice at birth
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• adult mice are smaller than control mice
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skeleton
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• at 2 months of age, mice fed a 0.81% calcium, 0.34% phosphorus, normal vitamin D diet show a reduction in whole body bone mineral density relative to control mice
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• femoral bone mineral density is reduced relative to than in control mice
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• mice exhibit reduced bone mineral deposition
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homeostasis/metabolism
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• urinary calcium concentrations tend to be lower than those in control mice (P = 0.15)
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• urinary phosphorus concentrations tend to be lower than those in control mice (P = 0.08)
• the urinary phosphorus concentration normalized for creatinine is higher than that in control mice
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digestive/alimentary system
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• following i.p. administration of 1alpha,25(OH)2D3, mice fail to show an increase in active intestinal calcium transport in everted gut sacs, unlike similarly treated wild-type controls where a ~2-fold increase is observed
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renal/urinary system
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• urinary calcium concentrations tend to be lower than those in control mice (P = 0.15)
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• urinary phosphorus concentrations tend to be lower than those in control mice (P = 0.08)
• the urinary phosphorus concentration normalized for creatinine is higher than that in control mice
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