Phenotypes associated with this allele

• Allele Symbol: Fgf3^tm1Lwd
• Allele Name: targeted mutation 1, Mark Lewandoski
• Allele ID: MGI:5888884
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fgf3^tm1Lwd/Fgf3^tm1Lwd Fgf4^tm1.1Lwd/Fgf4^tm1.2Lwd	involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J	MGI:5889000
cx2	Fgf3^tm1Lwd/Fgf3^tm1Lwd Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd	involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J	MGI:5888997

Genotype
MGI:5889000

cx1

• Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd; Fgf4^tm1.1Lwd/Fgf4^tm1.2Lwd
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

short rostral-caudal axis ( J:229949 )

• defects in the caudal axis extension

abnormal presomitic mesoderm morphology ( J:229949 )

• decreased length of tailbud presomitic mesoderm as compared to controls

limbs/digits/tail

decreased caudal vertebrae number ( J:229949 )

• decreased number of caudal vertebrae at E18.5

skeleton

decreased caudal vertebrae number ( J:229949 )

• decreased number of caudal vertebrae at E18.5

Genotype
MGI:5888997

cx2

• Allelic Composition: Fgf3^tm1Lwd/Fgf3^tm1Lwd; Fgf4^tm1.1Lwd/Fgf4^tm1.1Lwd
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J

behavior/neurological

head tilt ( J:229949 )

• 2/19 mice display circling or head-tilt behavior

circling ( J:229949 )

• 2/19 mice display circling or head-tilt behavior

embryo

abnormal presomitic mesoderm morphology ( J:229949 )

• decreased length of tailbud presomitic mesoderm as compared to controls

growth/size/body

decreased body size ( J:229949 )

limbs/digits/tail

short tail ( J:229949 )