All Phenotypes Slc44a2<tm1.2Tec> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc44a2^tm1.2Tec/Slc44a2^tm1.2Tec	FVB.129(Cg)-Slc44a2^tm1.2Tec	MGI:5881797
ht2	Slc44a2^tm1.2Tec/Slc44a2⁺	FVB.129(Cg)-Slc44a2^tm1.2Tec	MGI:5881799

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:239440 )

• mice are smaller than controls

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:239440 )

decreased cochlear inner hair cell number ( J:239440 )

• loss of inner hair cells throughout cochlea

decreased cochlear outer hair cell number ( J:239440 )

• loss of outer hair cells throughout cochlea

abnormal tunnel of Corti morphology ( J:239440 )

• basal turn of organ of Corti lacks the tunnel of Corti and any distinguishable hair cells; the apex and middle turns are near-normal

increased or absent threshold for auditory brainstem response ( J:239440 )

• elevated hearing threshold at 32 kHz beginning at 2 months

• hearing loss progresses at all frequencies (12 and 24 kHz) with age

increased susceptibility to age-related hearing loss ( J:239440 )

sensorineural hearing loss ( J:239440 )

nervous system

decreased cochlear inner hair cell number ( J:239440 )

• loss of inner hair cells throughout cochlea

decreased cochlear outer hair cell number ( J:239440 )

• loss of outer hair cells throughout cochlea

abnormal cochlear ganglion morphology ( J:239440 )

• decreased density of spiral ganglion cells in the basal turn of organ of Corti

• spiral ganglion cells in the basal turn of organ of Corti appear abnormal

Allelic Composition	Slc44a2^tm1.2Tec/Slc44a2⁺
Genetic Background	FVB.129(Cg)-Slc44a2^tm1.2Tec

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc44a2^tm1.2Tec mutation (0 available); any Slc44a2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:239440 )

decreased cochlear outer hair cell number ( J:239440 )

• outer hair cells are missing in the basal turn of the organ of Corti

increased or absent threshold for auditory brainstem response ( J:239440 )

• elevated hearing threshold at 32 kHz at 4 months, however, hearing loss is minimal at 12 and 24kHz frequencies

nervous system

decreased cochlear outer hair cell number ( J:239440 )

• outer hair cells are missing in the basal turn of the organ of Corti

abnormal cochlear ganglion morphology ( J:239440 )

• decreased density of spiral ganglion cells in the basal turn of organ of Corti

• spiral ganglion cells in the basal turn of organ of Corti appear abnormal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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