About   Help   FAQ
Targeted Allele Detail
Symbol: Slc44a2tm1.2Tec
Name: solute carrier family 44, member 2; targeted mutation 1.2, Thomas E Carey
MGI ID: MGI:5829833
Synonyms: Slc44a2delta
Gene: Slc44a2  Location: Chr9:21232015-21266324 bp, + strand  Genetic Position: Chr9, 7.77 cM
Alliance: Slc44a2tm1.2Tec page
Germline Transmission:  Earliest citation of germline transmission: J:239440
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector containing an FRT-flanked PGK-Neo selection cassette followed by a loxP site inserted upstream of exon 3 and another loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 10 floxed. Germ line, cre mediated recombination removed exons 3-10, which contain the first and largest extracellular loop of the protein. Immunoprecipitation of lung and kidney tissues confirmed that no protein was expressed in mutant mice. (J:239440)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc44a2 Mutation:  48 strains or lines available
Original:  J:239440 Kommareddi P, et al., Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2. J Assoc Res Otolaryngol. 2015 Dec;16(6):695-712
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.24
The Jackson Laboratory