Phenotypes associated with this allele

• Allele Symbol: Fgfr1^tm8.1Sor
• Allele Name: targeted mutation 8.1, Philippe Soriano
• Allele ID: MGI:5828622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr1^tm8.1Sor/Fgfr1^tm8.1Sor	129S4/SvJaeSor-Fgfr1^tm8.1Sor	MGI:5882536

Genotype
MGI:5882536

hm1

• Allelic Composition: Fgfr1^tm8.1Sor/Fgfr1^tm8.1Sor
• Genetic Background: 129S4/SvJaeSor-Fgfr1^tm8.1Sor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal axial skeleton morphology ( J:226497 )

• at P0, 2 of 15 homozygotes show axial skeleton defects

abnormal thoracic cage morphology ( J:226497 )

• 2 of 15 homozygotes show defects in the most posterior thoracic vertebrae and ribs

abnormal rib morphology ( J:226497 )

• one homozygote missing the 13th thoracic vertebra shows a rib rudiment on one side of the 12th thoracic vertebrae with a separated distal element of the rib present on the other side

• a second homozygote shows small rib rudiments present on the 13th thoracic vertebra

rib bifurcation ( J:226497 )

• 1 of 15 homozygotes shows bifurcation of the 4th rib

abnormal thoracic vertebrae morphology ( J:226497 )

• 1 of 15 homozygotes is missing the 13th thoracic vertebra while the ossification center of the 4th thoracic vertebra is duplicated and the attached rib is bifurcated

decreased thoracic vertebrae number ( J:226497 )

• 1 of 15 homozygotes is missing the 13th thoracic vertebra

decreased lumbar vertebrae number ( J:226497 )

• 2 of 15 homozygotes have five lumbar vertebrae

growth/size/body

growth/size/body region phenotype ( J:226497 )

N • homozygotes show normal postnatal growth relative to wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:226497 )

N • complete blood count and serum chemistries are normal