Fgfr1^tm8.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm8.1Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 8.1, Philippe Soriano
• MGI ID: MGI:5828622
• Synonyms: Fgfr1CPG, Fgfr1^CPG
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm8.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226497
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 10 was replaced with one in which nucleotide substitutions result in a silent mutation and the amino acid substitution of phenylalanine for tyrosine at position 463 (Y463F). Exon 18 was replaced with one in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 766 and 776 (Y766F, Y776F). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted in intron 9. (J:226497)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 221 strains or lines available

References

• Original: J:226497 Brewer JR, et al., Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev. 2015 Sep 1;29(17):1863-74
• All: 1 reference(s)