Phenotypes associated with this allele

• Allele Symbol: Tafazzin^tm1Dost
• Allele Name: targeted mutation 1, Douglas Strathdee
• Allele ID: MGI:5825473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tafazzin^tm1Dost/Y	involves: 129P2/OlaHsd	MGI:5825475

Genotype
MGI:5825475

ot1

• Allelic Composition: Tafazzin^tm1Dost/Y
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:238324 )

♂

abnormal spermatocyte morphology ( J:238324 )

♂ • increased DNA damage

abnormal male meiosis ( J:238324 )

♂ • disrupted chromosome synapsis

♂ • no pachytene stage spermatocytes are observed

abnormal testis morphology ( J:238324 )

♂ • abnormal vacuoles lacking maturing spermatocytes after the onset of meiosis

abnormal seminiferous tubule morphology ( J:238324 )

♂ • no spermatids and very few differentiated spermatocytes in tubules

♂ • fewer tubule numbers

small testis ( J:238324 )

♂

male infertility ( J:238324 )

♂

cardiovascular system

cardiovascular system phenotype ( J:238324 )

♂N • mice exhibit normal hearts

cellular

azoospermia ( J:238324 )

♂

abnormal spermatocyte morphology ( J:238324 )

♂ • increased DNA damage

abnormal male meiosis ( J:238324 )

♂ • disrupted chromosome synapsis

♂ • no pachytene stage spermatocytes are observed

endocrine/exocrine glands

abnormal testis morphology ( J:238324 )

♂ • abnormal vacuoles lacking maturing spermatocytes after the onset of meiosis

abnormal seminiferous tubule morphology ( J:238324 )

♂ • no spermatids and very few differentiated spermatocytes in tubules

♂ • fewer tubule numbers

small testis ( J:238324 )

♂