Tafazzin^tm1Dost
Targeted Allele Detail

Summary

• Symbol: Tafazzin^tm1Dost
• Name: tafazzin, phospholipid-lysophospholipid transacylase; targeted mutation 1, Douglas Strathdee
• MGI ID: MGI:5825473
• Synonyms: Taz^Neo
• Gene: Tafazzin Location: ChrX:73325518-73333757 bp, + strand Genetic Position: ChrX, 37.95 cM, cytoband C1-C3
• Alliance: Tafazzin^tm1Dost page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238324
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into intron 8. The insertion prevents expression of the last two exons. RT-PCR confirmed the absence of transcript expression in ES cells. (J:238324)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tafazzin Mutation: 3 strains or lines available

References

• Original: J:238324 Cadalbert LC, et al., Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis. PLoS One. 2015;10(6):e0131066
• All: 6 reference(s)